Single-layer graphene based SPR biochips for tuberculosis bacillus detection

Nan Fu Chiu, Teng Yi Huang, Chun Chuan Kuo, Wei Che Lee, Min Hua Hsieh, Hsin Chih Lai

    研究成果: 書貢獻/報告類型會議貢獻

    15 引文 斯高帕斯(Scopus)

    摘要

    This paper is intended to demonstrate a facile and effective method to construct single layer graphene films onto the self-assembled monolayer (SAM) at Au electrodes based surface plasmon resonance (SPR) biochips integrated loop-mediated isothermal amplification (LAMP) for tuberculosis bacillus (TB) detection. It is a novel Au-SAM-graphene nanocomposites and taking advantages of the striking properties of both graphene and Au film, fundamental understanding in hybrid material manipulation and new electrochemical properties can be obtained. The sensitivity of TB detection in the LAMP-based assay for the amplification of the Insertion Sequence 6110 (IS6110) samples was determined by a single-layer graphene/Au thin film and compared with that of a conventional Au/Cr-based SPR chips. The results show that a graphene/Au SPR offers a potentially powerful assay, with a highly sensitive analysis, that may be applicable as an important tool for bio-marker detection.

    原文英語
    主出版物標題Biophotonics
    主出版物子標題Photonic Solutions for Better Health Care III
    DOIs
    出版狀態已發佈 - 2012 六月 12
    事件Biophotonics: Photonic Solutions for Better Health Care III - Brussels, 比利时
    持續時間: 2012 四月 162012 四月 19

    出版系列

    名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
    8427
    ISSN(列印)1605-7422

    其他

    其他Biophotonics: Photonic Solutions for Better Health Care III
    國家比利时
    城市Brussels
    期間2012/04/162012/04/19

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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