Sequence and developmental expression of amphioxus AmphiNk2-1: Insights into the evolutionary origin of the vertebrate thyroid gland and forebrain

Tyamagondlu V. Venkatesh*, Nicholas D. Holland, Linda Z. Holland, Ming Tsan Su, Rolf Bodmer

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

71 引文 斯高帕斯(Scopus)

摘要

We characterized an amphioxus NK-2 homeobox gene (AmphiNk2-1), a homologue of vertebrate Nkx2-1, which is involved in the development of the central nervous system and thyroid gland. At the early neurula stage of amphioxus, AmphiNk2-1 expression is first detected medially in the neural plate. By the midneurula stage, expression is localized ventrally in the nerve cord and also begins in the endoderm. During the late neurula stage, the ventral neural expression becomes transiently segmented posteriorly and is then down-regulated except in the cerebral vesicle at the anterior end of the central nervous system. Within the cerebral vesicle AmphiNk2-1 is expressed in a broad ventral domain, probably comprising both the floor plate and basal plate regions; this pattern is comparable to Nkx2-1 expression in the mouse diencephalon. In the anterior part of the gut, expression becomes intense in the endostyle (the right wall of the pharynx), which is the presumed homologue of the vertebrate thyroid gland. More posteriorly there is transitory expression in the midgut and hindgut. In sum, the present results help to support homologies (1) between the amphioxus endostyle and the vertebrate thyroid gland and (2) between the amphioxus cerebral vesicle and the vertebrate diencephalic forebrain.

原文英語
頁(從 - 到)254-259
頁數6
期刊Development Genes and Evolution
209
發行號4
DOIs
出版狀態已發佈 - 1999
對外發佈

ASJC Scopus subject areas

  • 遺傳學
  • 發展生物學

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