Scaling characteristics of the magnetization increments of functionalized nanoparticles determined using a vibrating sample magnetometer for liquid magnetic immunoassays

Shu Hsien Liao, Han Sheng Huang, Yu Kai Su

研究成果: 雜誌貢獻文章

摘要

Here, scaling the normalized increment of dc magnetic susceptibility (Δχq/χq) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (ΔM) after binding the C-reactive protein (CRP) to Fe3O4–Vanti-CRP. The results show that ΔM increased when the concentration of CRP increased. There was enhanced ΔM generated from magnetic clusters composed of Fe3O4–Vanti-CRP–VCRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.

原文英語
文章編號8337743
頁(從 - 到)8990-8994
頁數5
期刊IEEE Sensors Journal
19
發行號20
DOIs
出版狀態接受/付印 - 2018 四月 12

指紋

immunoassay
Magnetometers
magnetometers
Magnetization
Nanoparticles
proteins
Proteins
scaling
nanoparticles
magnetization
Liquids
liquids
biomarkers
logistics
Biomolecules
viruses
Biomarkers
Hysteresis loops
Magnetic susceptibility
Viruses

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

引用此文

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title = "Scaling characteristics of the magnetization increments of functionalized nanoparticles determined using a vibrating sample magnetometer for liquid magnetic immunoassays",
abstract = "Here, scaling the normalized increment of dc magnetic susceptibility (Δχq/χq) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (ΔM) after binding the C-reactive protein (CRP) to Fe3O4–Vanti-CRP. The results show that ΔM increased when the concentration of CRP increased. There was enhanced ΔM generated from magnetic clusters composed of Fe3O4–Vanti-CRP–VCRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.",
keywords = "biofunctionalized magnetic nanoparticles, C-reactive protein, Magnetic hysteresis, magnetic immunoassays, Magnetic resonance imaging, Magnetic susceptibility, Magnetization, Magnetometers, Saturation magnetization, Superconducting magnets, vibrating sample magnetometers",
author = "Liao, {Shu Hsien} and Huang, {Han Sheng} and Su, {Yu Kai}",
year = "2018",
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T1 - Scaling characteristics of the magnetization increments of functionalized nanoparticles determined using a vibrating sample magnetometer for liquid magnetic immunoassays

AU - Liao, Shu Hsien

AU - Huang, Han Sheng

AU - Su, Yu Kai

PY - 2018/4/12

Y1 - 2018/4/12

N2 - Here, scaling the normalized increment of dc magnetic susceptibility (Δχq/χq) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (ΔM) after binding the C-reactive protein (CRP) to Fe3O4–Vanti-CRP. The results show that ΔM increased when the concentration of CRP increased. There was enhanced ΔM generated from magnetic clusters composed of Fe3O4–Vanti-CRP–VCRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.

AB - Here, scaling the normalized increment of dc magnetic susceptibility (Δχq/χq) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (ΔM) after binding the C-reactive protein (CRP) to Fe3O4–Vanti-CRP. The results show that ΔM increased when the concentration of CRP increased. There was enhanced ΔM generated from magnetic clusters composed of Fe3O4–Vanti-CRP–VCRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.

KW - biofunctionalized magnetic nanoparticles

KW - C-reactive protein

KW - Magnetic hysteresis

KW - magnetic immunoassays

KW - Magnetic resonance imaging

KW - Magnetic susceptibility

KW - Magnetization

KW - Magnetometers

KW - Saturation magnetization

KW - Superconducting magnets

KW - vibrating sample magnetometers

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