Scaling characteristics of the magnetization increments of functionalized nanoparticles determined using a vibrating sample magnetometer for liquid magnetic immunoassays

Shu Hsien Liao, Han Sheng Huang, Yu Kai Su

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

Here, scaling the normalized increment of dc magnetic susceptibility (Δχq/χq) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (ΔM) after binding the C-reactive protein (CRP) to Fe3O4–Vanti-CRP. The results show that ΔM increased when the concentration of CRP increased. There was enhanced ΔM generated from magnetic clusters composed of Fe3O4–Vanti-CRP–VCRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.

原文英語
文章編號8337743
頁(從 - 到)8990-8994
頁數5
期刊IEEE Sensors Journal
19
發行號20
DOIs
出版狀態接受/付印 - 2018 四月 12

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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