Sampling and profiling caffeine and its metabolites from an eyelid using a watercolor pen based on electrospray ionization/mass spectrometry

Yea Wenn Liou, Kai Yin Chang, Cheng Huang Lin

研究成果: 雜誌貢獻期刊論文同行評審

4 引文 斯高帕斯(Scopus)

摘要

A novel and non-invasive sampling method was developed for use in electrospray ionization/mass spectrometry (ESI/MS). The sampling tool, a watercolor pen (brush) that had been rinsed with ethanol, was used to collect analytes from the eyelids of volunteers. Following this, the brush was quickly moved to the front of the mass inlet, where the ethanol as well as the analytes evaporated very fast and escaped from the brush surface. When the analytes make contact with the ESI plume, which arises from the ESI needle tip, they are ionized and then detected by a mass spectrometer. The findings show that this new technique is applicable for the analysis of caffeine and its metabolites in samples obtained from eyelids after the volunteers consumed coffee. The methodology is simple and economical, non-invasive, and is suitable for use in monitoring the levels of caffeine and its metabolites over an extended period of time.

原文英語
頁(從 - 到)51-55
頁數5
期刊International Journal of Mass Spectrometry
422
DOIs
出版狀態已發佈 - 2017 十一月

ASJC Scopus subject areas

  • Instrumentation
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry

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