Risk of ADHD After Multiple Exposures to General Anesthesia: A Nationwide Retrospective Cohort Study

Chia Jui Tsai, Charles Tzu Chi Lee, Sophie Hsin Yi Liang, Pei Jung Tsai, Vincent Chin Hung Chen*, Michael Gossop

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

33 引文 斯高帕斯(Scopus)

摘要

Objective: To study the association between general anesthesia exposure before age 3 years and having a later ADHD diagnosis. Method: In a birth cohort, data were collected from a nationwide population database for children born between 1997 and 1999 who were exposed to general anesthesia before their third birthday. Age- and gender-matched enrollees without general anesthesia exposure were taken as the comparison. Groups were compared to identify the incidence of ADHD after age 4 and anesthesia-related predictive factors. Results: Among the 1,146 exposed children, 74 ADHD cases were identified, and 158 ADHD cases were identified in 3,438 matched controls. After adjusting for comorbid conditions and possible confounding factors, if exposure on more than one occasion or ≥3 hr, an increased likelihood of having a later ADHD diagnosis was found (HR, 1.71 and 2.43, respectively). Conclusion: Children with multiple or ≥3 hr general anesthesia exposures before age 3 years have an increased likelihood of a later ADHD diagnosis.

原文英語
頁(從 - 到)229-239
頁數11
期刊Journal of Attention Disorders
22
發行號3
DOIs
出版狀態已發佈 - 2018 2月 1

ASJC Scopus subject areas

  • 發展與教育心理學
  • 臨床心理學

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