Rhodium-Catalyzed Enantioselective Arylation of N-Substituted α,β-Unsaturated γ-Lactams: Preparation of Chiral 4-Aryl-2-Pyrrolidones

Jo Hsuan Fang, Chiung An Chang, Balraj Gopula, Ting Shen Kuo, Ping Yu Wu, Julian P. Henschke, Hsyueh Liang Wu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

12 引文 斯高帕斯(Scopus)

摘要

The preparation of chiral 4-aryl-2-pyrrolidones by conjugate addition catalyzed by a rhodium(I) complex, comprising the chiral bicyclo[2.2.1] diene ligand 1e, is reported. The reaction of various arylboronic acids and α,β-unsaturated γ-lactams 2 bearing various N-substituents proceeds in a highly stereoselective fashion (93-99.5% ee) even in the presence of only 0.5mol% of the Rh catalyst affording the corresponding addition products in 31-99% yield.

原文英語
頁(從 - 到)481-485
頁數5
期刊Asian Journal of Organic Chemistry
5
發行號4
DOIs
出版狀態已發佈 - 2016 四月 1

ASJC Scopus subject areas

  • 有機化學

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