Removal of lipopolysaccharide and reactive Oxygen species using sialic acid immobilized polysulfone dialyzer

Jung Jhih Chang, Po Jub Lin, Ming Chien Yang, Chiang-Ting Chien

研究成果: 雜誌貢獻期刊論文同行評審

4 引文 斯高帕斯(Scopus)

摘要

Sialic acid (N-acetylneuraminic acid, NANA) was covalently immobilized onto the surface of a polysulfone (PSF) hollow fiber membrane. Prior to the immobilization, the surface of PSF was treated with ozone, followed by grafting with acrylic acid, and then the esterification of NANA. The surface concentration of NANA was determined by 2-thiobarbituric acid (TBA) test. Hemocompatibility, the capability of suppressing oxidative stress, and clearance of lipopolysaccharide (LPS) from the resulting hollow fiber membrane were evaluated. The results show that by immobilizing NANA onto PSF hollow fiber, the adhesion of platelet was reduced, while both APTT and PT were little affected. Furthermore, oxidative stress was suppressed by NANA-immobilized PSF hollow fibers. The level of LPS was also greatly reduced.

原文英語
頁(從 - 到)871-877
頁數7
期刊Polymers for Advanced Technologies
20
發行號12
DOIs
出版狀態已發佈 - 2009 十二月 1

ASJC Scopus subject areas

  • 聚合物和塑料

指紋

深入研究「Removal of lipopolysaccharide and reactive Oxygen species using sialic acid immobilized polysulfone dialyzer」主題。共同形成了獨特的指紋。

引用此