Reinvestigation of the synthesis of 1-deazauridine

Cheng Hung Jen, Tun Cheng Chien

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

A thorough study for the synthesis of 1-deazauridine is described. 3-Bromo-2,6-dimethoxy-5-(-d-ribofuranosyl)pyridine, a synthetic precursor for 1-deazauridine, was prepared in seven steps from 2,6-dimethoxypyridine and d-ribose via the ribonolactone approach. Subsequent demethylation was unsuccessful but led to presumable anomerization and isomerization. The effort concluded that the synthesis of 1-deazauridine remained unachieved.

原文英語
頁(從 - 到)523-534
頁數12
期刊Nucleosides, Nucleotides and Nucleic Acids
29
發行號7
DOIs
出版狀態已發佈 - 2010 7月

ASJC Scopus subject areas

  • 生物化學
  • 分子醫學
  • 遺傳學

指紋

深入研究「Reinvestigation of the synthesis of 1-deazauridine」主題。共同形成了獨特的指紋。

引用此