Regulation of TOR complex 1 by amino acids through small GTPases

Joseph Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Joseph Rapley, Noriko Oshiro

研究成果: 書貢獻/報告類型篇章

摘要

TOR complex 1 (TORC1), composed of the TOR (target of rapamycin) protein kinase, the substrate binding subunit raptor, and the 36. kDa WD propellor protein Lst8/GβL, controls cell growth in all eukaryotes in response to nutrient availability, and in metazoans, to insulin and growth factors, energy status, and stress conditions. This chapter will focus on the mechanisms underlying mammalian TORC1 regulation by amino acids, in the context of overall TORC1 regulation in metazoan cells.

原文英語
主出版物標題Enzymes
發行者Academic Press
頁面57-73
頁數17
版本C
DOIs
出版狀態已發佈 - 2010

出版系列

名字Enzymes
號碼C
27
ISSN(列印)1874-6047

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biochemistry
  • Molecular Biology

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