@article{6c8bd627963548c6be6b95cfbdff8e09,
title = "Regioselective arylation of uracil and 4-pyridone derivatives via copper(I) bromide mediated C-H bond activation",
abstract = "A facile and effective synthesis of 6-aryluracil derivatives was accomplished by the direct C-H bond activation for arylation. A series of 6-aryl-1,3-dimethyluracils were synthesized from the reaction of 1,3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper(I) bromide as the catalyst and lithium tert-butoxide as the base. This methodology is applicable to a variety of 5-substituted uracils as well as 4-pyridone to provide direct accesses to versatile uracil and 4-pyridone derivatives.",
keywords = "4-Pyridone, Arylation, C-H activation, Catalysis, Uracil",
author = "Chien Cheng and Shih, {Yu Chiao} and Chen, {Hui Ting} and Chien, {Tun Cheng}",
note = "Funding Information: This work was supported by Research Grants 100-2113-M-003-007-MY2 and 100-2113-M-037-007 - from the National Science Council , Taiwan and NTNU100-D-06 from National Taiwan Normal University . ",
year = "2013",
month = jan,
day = "28",
doi = "10.1016/j.tet.2012.11.001",
language = "English",
volume = "69",
pages = "1387--1396",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "4",
}