Reduced structural integrity and functional lateralization of the dorsal language pathway correlate with hallucinations in schizophrenia: A combined diffusion spectrum imaging and functional magnetic resonance imaging study

Chen Hao Wu, Tzung Jeng Hwang, Pin Jane Chen, Tai Li Chou, Yung Chin Hsu, Chih Min Liu, Hsiao Lan Wang, Chung Ming Chen, Mau Sun Hua, Hai Gwo Hwu, Wen Yih Isaac Tseng

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

Recent studies suggest that structural and functional alterations of the language network are associated with auditory verbal hallucinations (AVHs) in schizophrenia. However, the ways in which the underlying structure and function of the network are altered and how these alterations are related to each other remain unclear. To elucidate this, we used diffusion spectrum imaging (DSI) to reconstruct the dorsal and ventral pathways and employed functional magnetic resonance imaging (fMRI) in a semantic task to obtain information about the functional activation in the corresponding regions in 18 patients with schizophrenia and 18 matched controls. The results demonstrated decreased structural integrity in the left ventral, right ventral and right dorsal tracts, and decreased functional lateralization of the dorsal pathway in schizophrenia. There was a positive correlation between the microstructural integrity of the right dorsal pathway and the functional lateralization of the dorsal pathway in patients with schizophrenia. Additionally, both functional lateralization of the dorsal pathway and microstructural integrity of the right dorsal pathway were negatively correlated with the scores of the delusion/hallucination symptom dimension. Our results suggest that impaired structural integrity of the right dorsal pathway is related to the reduction of functional lateralization of the dorsal pathway, and these alterations may aggravate AVHs in schizophrenia.

原文英語
頁(從 - 到)303-310
頁數8
期刊Psychiatry Research - Neuroimaging
224
發行號3
DOIs
出版狀態已發佈 - 2014 一月 1

    指紋

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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