@article{8819db8b24204165b5dcb48e2d51dbfe,
title = "Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation",
abstract = "A complementary study including design of mechanistic probes, biochemical assays, model analysis, and liquid chromatography coupled mass spectrometry was conducted to establish the reaction mechanism for a nonheme iron enzyme catalyzed (?)-podophyllotoxin formation. Our results indicate that the originally proposed hydroxylated intermediate is unlikely to be involved in this reaction. Instead, the formation of benzylic radical/carbocation intermediate can be utilized to trigger the C-C bond formation to construct the C-ring of (?)-podophyllotoxin.",
author = "Chang, {Wei Chen} and Yang, {Zhi Jie} and Tu, {Yueh Hua} and Chien, {Tun Cheng}",
note = "Funding Information: This work was supported by North Carolina State University, National Taiwan Normal University, and research grant MOST 107-2113-M-003-002 from Ministry of Science and Technology, Taiwan. We thank Dr. Bo Zhang at Penn State University, Prof. Yisong Guo at Carnegie Mellon University, and Prof. Christian Melander at University of Notre Dame for helpful discussion. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2019",
month = jan,
day = "4",
doi = "10.1021/acs.orglett.8b03670",
language = "English",
volume = "21",
pages = "228--232",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "1",
}