Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation

Wei Chen Chang*, Zhi Jie Yang, Yueh Hua Tu, Tun Cheng Chien

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

30 引文 斯高帕斯(Scopus)

摘要

A complementary study including design of mechanistic probes, biochemical assays, model analysis, and liquid chromatography coupled mass spectrometry was conducted to establish the reaction mechanism for a nonheme iron enzyme catalyzed (?)-podophyllotoxin formation. Our results indicate that the originally proposed hydroxylated intermediate is unlikely to be involved in this reaction. Instead, the formation of benzylic radical/carbocation intermediate can be utilized to trigger the C-C bond formation to construct the C-ring of (?)-podophyllotoxin.

原文英語
頁(從 - 到)228-232
頁數5
期刊Organic Letters
21
發行號1
DOIs
出版狀態已發佈 - 2019 1月 4

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

指紋

深入研究「Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation」主題。共同形成了獨特的指紋。

引用此