摘要
A complementary study including design of mechanistic probes, biochemical assays, model analysis, and liquid chromatography coupled mass spectrometry was conducted to establish the reaction mechanism for a nonheme iron enzyme catalyzed (?)-podophyllotoxin formation. Our results indicate that the originally proposed hydroxylated intermediate is unlikely to be involved in this reaction. Instead, the formation of benzylic radical/carbocation intermediate can be utilized to trigger the C-C bond formation to construct the C-ring of (?)-podophyllotoxin.
原文 | 英語 |
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頁(從 - 到) | 228-232 |
頁數 | 5 |
期刊 | Organic Letters |
卷 | 21 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 2019 1月 4 |
ASJC Scopus subject areas
- 生物化學
- 物理與理論化學
- 有機化學