Rapid synthesis of microwave-assisted zinc oxide nanorods on a paper-based analytical device for fluorometric detection of L-dopa

Yu Hsuan Lin, Yi Chun Yeh*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

L-dopa is a catecholamine neurotransmitter used to treat Parkinson's disease. This paper presents a low-cost paper-based biosensor aimed at enhancing the convenience of monitoring L-dopa concentrations. ZnO nanorods (ZnO-NRs) were synthesized on papers in less than 90 min using a microwave-assisted hydrothermal method. The ZnO-NRs amplify green fluorescence signals to enhance the detection sensitivity of L-dopa, best measured at excitation/emission wavelengths of 475/537 nm. We systematically characterized the effect of reaction conditions on the corresponding fluorescence enhancements. The proposed ZnO NRs-paper biosensor presented a ∼3-fold increase in green fluorescence compared to unmodified papers. The linear range of detection for L-dopa was 25–2000 nM, with a limit of detection of 24 nM, which meets the clinical requirements for the monitoring of L-dopa in Parkinson's patients.

原文英語
文章編號111995
期刊Colloids and Surfaces B: Biointerfaces
207
DOIs
出版狀態已發佈 - 2021 十一月

ASJC Scopus subject areas

  • 生物技術
  • 表面和介面
  • 物理與理論化學
  • 膠體和表面化學

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