Rapid screening and determination of designer drugs in saliva by a nib-assisted paper spray-mass spectrometry and separation technique

Hsun Lee, Chih Sheng Jhang, Ju Tsung Liu, Cheng Huang Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

34 引文 斯高帕斯(Scopus)

摘要

A method for the rapid screening and determination of amphetamine-type designer drugs in saliva by a novel nib-assisted paper spray-mass spectrometry procedure is described. Under optimized conditions, the limit of detections for amphetamine derivatives (model samples: o-, m-, p-chloroamphetamine and o-, m-, p-fluoroamphetamine, respectively) were determined to 0.1 μg/mL by the nib-assisted paper spray-mass spectrometry method. This method is easier and has a higher sensitivity than similar methodologies, including atmospheric pressure/matrix-assisted laser desorption ionization mass spectrometry and electrospray-assisted laser desorption ionization/mass spectrometry. Data obtained using more classical separation methods, including liquid chromatography and capillary electrophoresis, are also reported.

原文英語
頁(從 - 到)2822-2825
頁數4
期刊Journal of Separation Science
35
發行號20
DOIs
出版狀態已發佈 - 2012 10月

ASJC Scopus subject areas

  • 分析化學
  • 篩選和分離

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