TY - JOUR
T1 - Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry
AU - Su, An Kai
AU - Liu, Ju Tsung
AU - Lin, Cheng Huang
N1 - Funding Information:
This work was supported by a grant from the National Science Council of Taiwan under Contract No. NSC-92-2113-M-003-023. Permission was obtained from Pharmaceutical Affairs, Department of Health, Taiwan (License Number: ARR089000035).
PY - 2005/10/15
Y1 - 2005/10/15
N2 - A novel method for the rapid screening of clandestine tablets for drugs by MALDI-TOF mass spectrometry is described. In this method, cetrimonium bromide (CTAB), a surfactant, is added to the conventional α-cyano-4- hydroxycinnamic acid (CHCA) matrix solution used in preparing the MALDI samples. This procedure allows very clean mass spectra to be collected for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4- methylenedioxymethamphetamine (MDMA), caffeine, ketamine and tramadol. The method was used successfully in the rapid drug-screening of some actual clandestine tablets, which had been seized from the illicit market, and can serve as a good complementary method to GC/MS for use in forensic analysis.
AB - A novel method for the rapid screening of clandestine tablets for drugs by MALDI-TOF mass spectrometry is described. In this method, cetrimonium bromide (CTAB), a surfactant, is added to the conventional α-cyano-4- hydroxycinnamic acid (CHCA) matrix solution used in preparing the MALDI samples. This procedure allows very clean mass spectra to be collected for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4- methylenedioxymethamphetamine (MDMA), caffeine, ketamine and tramadol. The method was used successfully in the rapid drug-screening of some actual clandestine tablets, which had been seized from the illicit market, and can serve as a good complementary method to GC/MS for use in forensic analysis.
KW - CHCA
KW - Clandestine tablet
KW - CTAB
KW - MALDI-TOF mass spectrometry
KW - Rapid drug-screening
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U2 - 10.1016/j.talanta.2005.03.013
DO - 10.1016/j.talanta.2005.03.013
M3 - Article
AN - SCOPUS:24344450298
VL - 67
SP - 718
EP - 724
JO - Talanta
JF - Talanta
SN - 0039-9140
IS - 4
ER -