Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry

An Kai Su, Ju Tsung Liu, Cheng Huang Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

27 引文 斯高帕斯(Scopus)

摘要

A novel method for the rapid screening of clandestine tablets for drugs by MALDI-TOF mass spectrometry is described. In this method, cetrimonium bromide (CTAB), a surfactant, is added to the conventional α-cyano-4- hydroxycinnamic acid (CHCA) matrix solution used in preparing the MALDI samples. This procedure allows very clean mass spectra to be collected for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4- methylenedioxymethamphetamine (MDMA), caffeine, ketamine and tramadol. The method was used successfully in the rapid drug-screening of some actual clandestine tablets, which had been seized from the illicit market, and can serve as a good complementary method to GC/MS for use in forensic analysis.

原文英語
頁(從 - 到)718-724
頁數7
期刊Talanta
67
發行號4
DOIs
出版狀態已發佈 - 2005 10月 15

ASJC Scopus subject areas

  • 分析化學

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