Protein synthesis in the hippocampus associated with memory facilitation by corticotropin-releasing factor in rats

E. H.Y. Lee, H. C. Hung, K. T. Lu, W. H. Chen, H. Y. Chen

研究成果: 雜誌貢獻期刊論文同行評審

60 引文 斯高帕斯(Scopus)

摘要

The present study used pharmacological, biochemical, and behavioral methods to examine the role of protein synthesis in the hippocampus in memory processes of a passive avoidance learning in rats. Results indicated that corticotropin-releasing factor (CRF) significantly improved memory retention in rats. Both cycloheximide (CHX) and actinomycin-D (ACT-D) impaired memory at high doses. At doses of CHX and ACT-D that did not affect memory alone, they both antagonized the memory-enhancing effect of CRF. Biochemically, there were specific increases in the optical density of three protein bands in the cytosolic fraction of hippocampal cells in rats showing good memory. There were also marked increases in the optical density of two protein bands in the nucleus fraction of the same animals. Similar results were observed in animals injected with CRF. However, no significant protein alteration was observed in animals receiving stress. These results together suggest that there are new protein syntheses in the hippocampus that are specifically associated with passive avoidance learning in rats.

原文英語
頁(從 - 到)927-937
頁數11
期刊Peptides
13
發行號5
DOIs
出版狀態已發佈 - 1992

ASJC Scopus subject areas

  • 生物化學
  • 生理學
  • 內分泌
  • 細胞與分子神經科學

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