Protective role of metallothionein (I/II) against pathological damage and apoptosis induced by dimethylarsinic acid

Guang Jia, Yi Qun Gu, Kung Tung Chen, You Yong Lu, Lei Yan, Jian Ling Wang, Ya Ping Su, J. C.Gaston Wu

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Aim: To better clarify the main target organs of dimethylarsinic acid toxicity and the role of metallothionein (MTs) in modifying dimethylarsinic acid (DMAA) toxicity. Methods: MT-I/II null (MT-/-) mice and the corresponding wild-type mice (MT+/+), six in each group, were exposed to DMAA (0-750 mg/kg body weight) by a single oral injection. Twenty four hours later, the lungs, livers and kidneys were collected and undergone pathological analysis, induction of apoptotic cells as determined by TUNEL and MT concentration was detected by radio-immunoassay. Results: Remarkable pathological lesions were observed at the doses ranging from 350 to 750 mg/kg body weight in the lungs, livers and kidneys and MT+/+ mice exhibited a relatively slight destruction when compared with that in dose matched MT+/+ mice. The number of apoptotic cells was increased in a dose dependent manner in the lungs and livers in both types of mice. DMAA produced more necrotic cells rather than apoptotic cells at the highest dose of 750 mg/kg, however, no significant increase was observed in the kidney. Hepatic MT level in MT+/+ mice was significantly increased by DMAA in a dose-dependent manner and there was no detectable amount of hepatic MT in untreated MT-/- mice. Conclusion: DMAA treatment can lead to the induction of apoptosis and pathological damage in both types of mice. MT exhibits a protective effect against DMAA toxicity.

原文英語
頁(從 - 到)91-95
頁數5
期刊World Journal of Gastroenterology
10
發行號1
DOIs
出版狀態已發佈 - 2004 一月

ASJC Scopus subject areas

  • Gastroenterology

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