Propofol infusion shortens and attenuates oxidative stress during one lung ventilation

Chi Hsiang Huang, Yong Pin Wang, Pei Yu Wu, Chiang Ting Chien, Ya Jung Cheng*


研究成果: 雜誌貢獻期刊論文同行評審

24 引文 斯高帕斯(Scopus)


Background: Resuming two lung ventilation (2LV) from one lung ventilation (OLV) has been proven to induce significant oxidative stress, mainly by superoxide release. Although total intravenous anesthesia and inhalational anesthesia are both used in thoracic surgery, different anesthetics may alter the oxidant/antioxidant balance. Methods: Thirty patients undergoing thoracic surgery were randomly allocated to the propofol infusion (intravenous) group or isoflurane (inhalational) group after induction and placement of a double lumen endobronchial tube. Reactive oxygen species (ROS) production and total antioxidant status (TAS) were measured during OLV and 2LV manipulations. Blood samples were taken in the lateral position before OLV (T1), immediately before resuming 2LV (T2), and 5 minutes (T3) and 20 minutes (T4) after resuming 2LV, for measurement of ROS. Results: ROS production increased significantly at T3 and T4 in both groups but to a lesser extent in the propofol infusion group. TAS levels increased with time in the propofol group but not in the isoflurane group. Conclusion: Propofol infusion, compared with isoflurane inhalation, attenuates ROS production and limits it for 20 minutes after resuming 2LV from OLV. Propofol infusion may be beneficial to patients with inadequate antioxidant capacity.

頁(從 - 到)160-165
期刊Acta Anaesthesiologica Taiwanica
出版狀態已發佈 - 2008 12月

ASJC Scopus subject areas

  • 麻醉與疼痛醫學


深入研究「Propofol infusion shortens and attenuates oxidative stress during one lung ventilation」主題。共同形成了獨特的指紋。