Preparation of highly functionalized arylmagnesium reagents by the addition of magnesium phenylselenide to arynes

Wenwei Lin, Florian Ilgen, Paul Knochel

研究成果: 雜誌貢獻期刊論文同行評審

24 引文 斯高帕斯(Scopus)

摘要

The described polyfunctional arylmagnesium reagents, resulting from the highly regioselective addition of magnesium phenylselenide to functionalized arynes, can be trapped by a range of electrophiles, yielding polyfunctional selenoethers in 45-85% yields. Furthermore, these Grignard reagents can be used in Negishi cross-coupling reactions with iodoarenes after transmetalation to the corresponding arylzinc compounds, furnishing functionalized biaryl products in 55-73% yields.

原文英語
頁(從 - 到)1941-1944
頁數4
期刊Tetrahedron Letters
47
發行號12
DOIs
出版狀態已發佈 - 2006 三月 20

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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