Preparation of functionalized aryl magnesium reagents by the addition of magnesium aryl thiolates and amides to arynes

Wenwei Lin; Ioannis Sapountzis; Paul Knochel

doi:10.1002/anie.200500443

Preparation of functionalized aryl magnesium reagents by the addition of magnesium aryl thiolates and amides to arynes

Wenwei Lin^*
, Ioannis Sapountzis
, Paul Knochel

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

100 引文斯高帕斯（Scopus）

摘要

(Chemical Equation Presented) Reactive arynes, which are readily generated by the reaction of ortho-iocloarylsulfonates with iPrMgCl, undergo the smooth addition of various magnesium nucleophiles like magnesium thiolates, selenides, and amides. In all cases the resulting functionalized aryl magnesium species can be trapped by an electrophile leading to highly functionalized aromatic compounds (see scheme).

原文	英語
頁（從 - 到）	4258-4261
頁數	4
期刊	Angewandte Chemie - International Edition
卷	44
發行號	27
DOIs	https://doi.org/10.1002/anie.200500443
出版狀態	已發佈 - 2005 7月 4
對外發佈	是

ASJC Scopus subject areas

催化
一般化學

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10.1002/anie.200500443

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abstract = "(Chemical Equation Presented) Reactive arynes, which are readily generated by the reaction of ortho-iocloarylsulfonates with iPrMgCl, undergo the smooth addition of various magnesium nucleophiles like magnesium thiolates, selenides, and amides. In all cases the resulting functionalized aryl magnesium species can be trapped by an electrophile leading to highly functionalized aromatic compounds (see scheme).",

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AU - Lin, Wenwei

AU - Sapountzis, Ioannis

AU - Knochel, Paul

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Y1 - 2005/7/4

N2 - (Chemical Equation Presented) Reactive arynes, which are readily generated by the reaction of ortho-iocloarylsulfonates with iPrMgCl, undergo the smooth addition of various magnesium nucleophiles like magnesium thiolates, selenides, and amides. In all cases the resulting functionalized aryl magnesium species can be trapped by an electrophile leading to highly functionalized aromatic compounds (see scheme).

AB - (Chemical Equation Presented) Reactive arynes, which are readily generated by the reaction of ortho-iocloarylsulfonates with iPrMgCl, undergo the smooth addition of various magnesium nucleophiles like magnesium thiolates, selenides, and amides. In all cases the resulting functionalized aryl magnesium species can be trapped by an electrophile leading to highly functionalized aromatic compounds (see scheme).

KW - Amination

KW - Arynes

KW - Grignard reagents

KW - Heterocycles

KW - Thioethers

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 27

ER -

Preparation of functionalized aryl magnesium reagents by the addition of magnesium aryl thiolates and amides to arynes

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