Preparation of functionalized 3,4-pyridynes via 2-magnesiated diaryl sulfonates

Wenwei Lin, Ling Chen, Paul Knochel*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

46 引文 斯高帕斯(Scopus)

摘要

The preparation of functionalized 3,4-pyridynes of type 1 as highly reactive intermediates has been achieved by the controlled elimination of readily generated 2-magnesiated diaryl sulfonates of type 2 obtained by a low temperature I/Mg- or Br/Mg-exchange starting from the corresponding halides of type 3. After trapping with furan, moderate to good yields of the desired functionalized cycloadducts of type 4 are obtained. The addition of a magnesium arylthiolate or magnesium phenylselenide to 3,4-pyridyne followed by quenching with an electrophile is also described.

原文英語
頁(從 - 到)2787-2797
頁數11
期刊Tetrahedron
63
發行號13
DOIs
出版狀態已發佈 - 2007 三月 26

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

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