Practically acquired and modified cone-beam computed tomography images for accurate dose calculation in head and neck cancer

Chih Chung Hu, Wen Tao Huang, Chiao Ling Tsai, Jian Kuen Wu, Hsiao Ling Chao, Guo Ming Huang, Chun Wei Wang, Chien-Jang Wu, Jason Chia Hsien Cheng*

*此作品的通信作者

    研究成果: 雜誌貢獻期刊論文同行評審

    8 引文 斯高帕斯(Scopus)

    摘要

    Background: On-line cone-beam computed tomography (CBCT) may be used to reconstruct the dose for geometric changes of patients and tumors during radiotherapy course. This study is to establish a practical method to modify the CBCT for accurate dose calculation in head and neck cancer. Patients and Methods: Fan-beam CT (FBCT) and Elekta's CBCT were used to acquire images. The CT numbers for different materials on CBCT were mathematically modified to match them with FBCT. Three phantoms were scanned by FBCT and CBCT for image uniformity, spatial resolution, and CT numbers, and to compare the dose distribution from orthogonal beams. A Rando phantom was scanned and planned with intensity-modulated radiation therapy (IMRT). Finally, two nasopharyngeal cancer patients treated with IMRT had their CBCT image sets calculated for dose comparison. Results: With 360° acquisition of CBCT and high-resolution reconstruction, the uniformity of CT number distribution was improved and the otherwise large variations for background and high-density materials were reduced significantly. The dose difference between FBCT and CBCT was < 2% in phantoms. In the Rando phantom and the patients, the dose-volume histograms were similar. The corresponding isodose curves covering ≥ 90% of prescribed dose on FBCT and CBCT were close to each other (within 2 mm). Most dosimetric differences were from the setup errors related to the interval changes in body shape and tumor response. Conclusion: The specific CBCT acquisition, reconstruction, and CT number modification can generate accurate dose calculation for the potential use in adaptive radiotherapy.

    原文英語
    頁(從 - 到)633-644
    頁數12
    期刊Strahlentherapie und Onkologie
    187
    發行號10
    DOIs
    出版狀態已發佈 - 2011 十月 1

    ASJC Scopus subject areas

    • 放射學、核子醫學和影像學
    • 腫瘤科

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