Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction

Yu Chiao Shih; Tun Cheng Chien

doi:10.1016/j.tet.2011.03.051

Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction

Yu Chiao Shih
, Tun Cheng Chien^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

25 引文斯高帕斯（Scopus）

摘要

Sugar-protected 6-halouridine derivatives underwent Suzuki-Miyaura cross-coupling reactions with arylboronic acids in the presence of palladium(II) acetate as a catalyst, triphenylphosphine as a ligand, and sodium carbonate as a base. This methodology is applicable to both the C5- and C6-position of uridine and provides a direct access for versatile uridine derivatives.

原文	英語
頁（從 - 到）	3915-3923
頁數	9
期刊	Tetrahedron
卷	67
發行號	21
DOIs	https://doi.org/10.1016/j.tet.2011.03.051
出版狀態	已發佈 - 2011 5月 27

ASJC Scopus subject areas

生物化學
藥物發現
有機化學

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10.1016/j.tet.2011.03.051

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title = "Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction",

abstract = "Sugar-protected 6-halouridine derivatives underwent Suzuki-Miyaura cross-coupling reactions with arylboronic acids in the presence of palladium(II) acetate as a catalyst, triphenylphosphine as a ligand, and sodium carbonate as a base. This methodology is applicable to both the C5- and C6-position of uridine and provides a direct access for versatile uridine derivatives.",

keywords = "Boronic acid, Cross-coupling, Nucleoside, Suzuki-Miyaura, Uridine",

author = "Shih, \{Yu Chiao\} and Chien, \{Tun Cheng\}",

note = "Funding Information: This work was supported by Research Grant 97-2113-M-003-001-MY2 from the National Science Council , Taiwan. We are grateful to the National Center for High-performance Computing of Taiwan for the electronic resources and facilities. ",

year = "2011",

month = may,

day = "27",

doi = "10.1016/j.tet.2011.03.051",

language = "English",

volume = "67",

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T1 - Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction

AU - Shih, Yu Chiao

AU - Chien, Tun Cheng

N1 - Funding Information: This work was supported by Research Grant 97-2113-M-003-001-MY2 from the National Science Council , Taiwan. We are grateful to the National Center for High-performance Computing of Taiwan for the electronic resources and facilities.

PY - 2011/5/27

Y1 - 2011/5/27

N2 - Sugar-protected 6-halouridine derivatives underwent Suzuki-Miyaura cross-coupling reactions with arylboronic acids in the presence of palladium(II) acetate as a catalyst, triphenylphosphine as a ligand, and sodium carbonate as a base. This methodology is applicable to both the C5- and C6-position of uridine and provides a direct access for versatile uridine derivatives.

AB - Sugar-protected 6-halouridine derivatives underwent Suzuki-Miyaura cross-coupling reactions with arylboronic acids in the presence of palladium(II) acetate as a catalyst, triphenylphosphine as a ligand, and sodium carbonate as a base. This methodology is applicable to both the C5- and C6-position of uridine and provides a direct access for versatile uridine derivatives.

KW - Boronic acid

KW - Cross-coupling

KW - Nucleoside

KW - Suzuki-Miyaura

KW - Uridine

UR - https://www.scopus.com/pages/publications/79955666014

UR - https://www.scopus.com/pages/publications/79955666014#tab=citedBy

U2 - 10.1016/j.tet.2011.03.051

DO - 10.1016/j.tet.2011.03.051

M3 - Article

AN - SCOPUS:79955666014

SN - 0040-4020

VL - 67

SP - 3915

EP - 3923

JO - Tetrahedron

JF - Tetrahedron

IS - 21

ER -

Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction

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