Pneumococcal pneumonia infection is associated with end-stage renal disease in adult hospitalized patients

Shih Ting Huang, Cheng Li Lin, Yen Jung Chang, Yuh Pyng Sher, Ming Ju Wu, Kuo Hsiung Shu, Fung Chang Sung, Chia Hung Kao*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

20 引文 斯高帕斯(Scopus)

摘要

Pneumococcal disease leads to renal complications ranging from persistent proteinuria to end-stage renal disease (ESRD) in pediatric patients. However, long-term renal effects after pneumococcal pneumonia infection in adult patients remains largely unknown. To evaluate this we conducted a population-based retrospective cohort study consisting of 18,733 adult patients at the time of pneumococcal pneumonia diagnosis, using claims data from Taiwan's National Health Insurance Research Database (NHIRD) with a comparison cohort of 73,409 age- and gender-matched patients without pneumococcal pneumonia. The overall incidence rate ratio of ESRD was 23% higher in those with pneumococcal pneumonia than in those without pneumococcal pneumonia (5.26 vs. 3.10 per 1000 person-years), with an adjusted hazard ratio of 1.14 (95% confidence interval 1.01-1.29). In addition, the risk of developing ESRD was associated with covariates including age, gender, chronic kidney disease, diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, and heart failure. The ESRD cumulative incidence curve showed a considerably higher risk of ESRD in those with pneumococcal pneumonia than in those without pneumococcal pneumonia (significant by log-rank test). Thus, pneumococcal pneumonia may be associated with an increased risk of ESRD in adult patients. A long-term follow-up of renal function is recommended for adult hospitalized patients with pneumococcal pneumonia infection.

原文英語
頁(從 - 到)1023-1030
頁數8
期刊Kidney International
86
發行號5
DOIs
出版狀態已發佈 - 2014 十一月 5

ASJC Scopus subject areas

  • 腎臟病學

指紋

深入研究「Pneumococcal pneumonia infection is associated with end-stage renal disease in adult hospitalized patients」主題。共同形成了獨特的指紋。

引用此