Plasmonic biosensor detected human chorionic gonadotropin with naked eye

Yu Chieh Yen, Nan Fu Chiu

研究成果: 書貢獻/報告類型會議貢獻

摘要

The traditional surface plasmon resonance (SPR) instrument has the advantages of real time, label-free and high sensitivity. This study mainly makes the traditional SPR instruments miniaturized into active plasmon colorimetric biosensors, which is used for point of care and further improve the medical Level. Nano-printed technology is a simple process technology that used in the preparation of nano-structure with advantages of low cost and high production, for the future active plasmon colorimetric biosensors manufacturing has a very high Production advantages. Organic light emitting diodes have the uniformity of light intensity at different angles, which is one of the indispensable conditions in the detection process of plasmon bioassay. In this experiment, it is proved that the grating period is 555 nm, when the refraction value change from 1 to 1.33 the coupling wavelength shifted about 190 nm, the minimum refractive index is 1.736×10-3 RIU. The binding reaction with β-hCG (1 μM) was enhanced by the bonding of Peptide (1 mM) with gold nanoparticles (15 nm), which was about 43.88 times higher than that of the original peptide (1 mM) and β-hCG (1 μM). That the minimum refraction value of the change in the sensitivity increased to 3.956×10-5 RIU. After the peptides (33 nm) bonded Peptide (1 mM) and β-hCG (1 μM) were used for the active plasmon colorimetric biosensors. The plasmon at a measuring angle of 5 ° wavelength of the emission shifted 16 nm, and the measurement angle is 4 nm at the measuring angle of -5 °.

原文英語
主出版物標題Optical Sensors 2019
編輯Francesco Baldini, Jiri Homola, Robert A. Lieberman
發行者SPIE
ISBN(電子)9781510627222
DOIs
出版狀態已發佈 - 2019 一月 1
事件Optical Sensors 2019 - Prague, 捷克共和国
持續時間: 2019 四月 12019 四月 4

出版系列

名字Proceedings of SPIE - The International Society for Optical Engineering
11028
ISSN(列印)0277-786X
ISSN(電子)1996-756X

會議

會議Optical Sensors 2019
國家捷克共和国
城市Prague
期間19/4/119/4/4

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • 引用此

    Yen, Y. C., & Chiu, N. F. (2019). Plasmonic biosensor detected human chorionic gonadotropin with naked eye. 於 F. Baldini, J. Homola, & R. A. Lieberman (編輯), Optical Sensors 2019 [1102823] (Proceedings of SPIE - The International Society for Optical Engineering; 卷 11028). SPIE. https://doi.org/10.1117/12.2520930