Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease

Kai Yuan Tzen, Shieh Yueh Yang, Ta Fu Chen, Ting Wen Cheng, Herng Er Horng, Hsiang Ping Wen, Ya Yao Huang, Chyng Yann Shiue, Ming Jang Chiu*


研究成果: 雜誌貢獻期刊論文同行評審

89 引文 斯高帕斯(Scopus)


Recent advances in biomarkers provide the possibility of early or preclinical diagnosis of Alzheimer's pathology. Currently, decreased levels of Aβ-42 and increased levels of tau proteins in cerebral spinal fluid are considered reliable biomarkers of Alzheimer's disease (AD); however, little evidence exists for the use of amyloid and tau protein levels in the plasma as useful biomarkers. We investigated the potential use of plasma biomarkers to diagnose AD and explored their relationships with brain Aβ deposition in amyloid imaging. We used an immunomagnetic reduction assay to measure the plasma levels of Aβ40, Aβ42, and tau proteins in 20 older control participants and 25 participants who had either mild cognitive impairment due to AD or early AD dementia. All participants received 11C-labeled Pittsburgh compound B PET scans. The sensitivity of the plasma tau level at the cutoff value of 28.27 pg/mL was 92%, and the specificity was 100%; the sensitivity of the Aβ42/40 ratio at the cutoff value of 0.3693 was 84%, and the specificity was 100%. Regression analyses of the effects of plasma protein levels on brain amyloid retention, as determined by standard uptake value ratios in either side of the frontal, parietal, and temporal lobes and the precuneus, are predicted only by ratios of plasma Aβ42/40 (R2 0.326-0.449, all p < 0.001) but not by plasma tau levels. Plasma Aβ in terms of Aβ42/40 might provide an indirect estimation of Aβ deposition in the brain.

頁(從 - 到)830-836
期刊ACS Chemical Neuroscience
出版狀態已發佈 - 2014 9月 17

ASJC Scopus subject areas

  • 生物化學
  • 生理學
  • 認知神經科學
  • 細胞生物學


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