Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai Ci Chan; Pei Ya Shan; Men Hsin Wu; Pin Han Lin; Chang Shun Tsai; Chia Chien Hsu; Ting Hsiang Chiu; Ting Wei Hsu; Yi Cheun Yeh; Yun Ju Lai; Wei Min Liu; Ling Hsien Tu

doi:10.1039/d3cc03363e

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai Ci Chan
, Pei Ya Shan
, Men Hsin Wu
, Pin Han Lin
, Chang Shun Tsai
, Chia Chien Hsu
, Ting Hsiang Chiu
, Ting Wei Hsu
, Yi Cheun Yeh
, Yun Ju Lai^*
, Wei Min Liu^*
, Ling Hsien Tu^*

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

原文	英語
頁（從 - 到）	10660-10663
頁數	4
期刊	Chemical Communications
卷	59
發行號	71
DOIs	https://doi.org/10.1039/d3cc03363e
出版狀態	已發佈 - 2023 8月 4

ASJC Scopus subject areas

電子、光磁材料
催化
陶瓷和複合材料
一般化學
表面、塗料和薄膜
金屬和合金
材料化學

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10.1039/d3cc03363e

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title = "Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity",

abstract = "Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.",

author = "Chan, \{Ai Ci\} and Shan, \{Pei Ya\} and Wu, \{Men Hsin\} and Lin, \{Pin Han\} and Tsai, \{Chang Shun\} and Hsu, \{Chia Chien\} and Chiu, \{Ting Hsiang\} and Hsu, \{Ting Wei\} and Yeh, \{Yi Cheun\} and Lai, \{Yun Ju\} and Liu, \{Wei Min\} and Tu, \{Ling Hsien\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = aug,

day = "4",

doi = "10.1039/d3cc03363e",

language = "English",

volume = "59",

pages = "10660--10663",

journal = "Chemical Communications",

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TY - JOUR

T1 - Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

AU - Chan, Ai Ci

AU - Shan, Pei Ya

AU - Wu, Men Hsin

AU - Lin, Pin Han

AU - Tsai, Chang Shun

AU - Hsu, Chia Chien

AU - Chiu, Ting Hsiang

AU - Hsu, Ting Wei

AU - Yeh, Yi Cheun

AU - Lai, Yun Ju

AU - Liu, Wei Min

AU - Tu, Ling Hsien

PY - 2023/8/4

Y1 - 2023/8/4

N2 - Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

AB - Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

UR - https://www.scopus.com/pages/publications/85169298607

UR - https://www.scopus.com/pages/publications/85169298607#tab=citedBy

U2 - 10.1039/d3cc03363e

DO - 10.1039/d3cc03363e

M3 - Article

C2 - 37581279

AN - SCOPUS:85169298607

SN - 1359-7345

VL - 59

SP - 10660

EP - 10663

JO - Chemical Communications

JF - Chemical Communications

IS - 71

ER -

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

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ASJC Scopus subject areas

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