Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai Ci Chan, Pei Ya Shan, Men Hsin Wu, Pin Han Lin, Chang Shun Tsai, Chia Chien Hsu, Ting Hsiang Chiu, Ting Wei Hsu, Yi Cheun Yeh, Yun Ju Lai*, Wei Min Liu*, Ling Hsien Tu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

原文英語
頁(從 - 到)10660-10663
頁數4
期刊Chemical Communications
59
發行號71
DOIs
出版狀態已發佈 - 2023 8月 4

ASJC Scopus subject areas

  • 電子、光磁材料
  • 催化
  • 陶瓷和複合材料
  • 一般化學
  • 表面、塗料和薄膜
  • 金屬和合金
  • 材料化學

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