TY - JOUR
T1 - Phytochemical constituents from dietary plant Citrus hystrix
AU - Sadasivam, Mathusalini
AU - Kumarasamy, Chandraprakash
AU - Thangaraj, Arasakumar
AU - Govindan, Mani
AU - Kasirajan, Gayathri
AU - Vijayan, Viswanathan
AU - Devadasan, Velmurugan
AU - Chia-Her, Lin
AU - Madhusudhanan, Gogul Ramnath
AU - Ramaraj, Thirugnanasampandan
AU - Palathurai Subramaniam, Mohan
N1 - Publisher Copyright:
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/7/18
Y1 - 2018/7/18
N2 - Chemical investigation of the fruit peel of dietary plant Citrus hystrix offered two new flavones 5,6,4′-trihydroxypyranoflavone I and 5,4′-dimethyl-6-prenylpyranoflavone XIII besides 11 known compounds. The structures of all compounds were elucidated with the aid of suitable analytical methods like 1D, 2D-NMR, mass and single crystal X-ray analysis. An X-ray crystal study of compound II was done for the first time and the compounds I–VI, XI and XII are hitherto not reported from this plant. Biological studies revealed that compound I found to have a good antidiabetic and antiacetylcholinesterase activities meanwhile compounds II, III and V showed a significant free radical scavenging ability as well as antioxidant capacity. In addition, compounds I, IV, V and VI showed cytotoxicity against U87, A549 and MCF-7 cells. Overall, the new compound I showed valuable bioactive properties. Due to insufficient quantity of compound XIII, biological studies were not done.
AB - Chemical investigation of the fruit peel of dietary plant Citrus hystrix offered two new flavones 5,6,4′-trihydroxypyranoflavone I and 5,4′-dimethyl-6-prenylpyranoflavone XIII besides 11 known compounds. The structures of all compounds were elucidated with the aid of suitable analytical methods like 1D, 2D-NMR, mass and single crystal X-ray analysis. An X-ray crystal study of compound II was done for the first time and the compounds I–VI, XI and XII are hitherto not reported from this plant. Biological studies revealed that compound I found to have a good antidiabetic and antiacetylcholinesterase activities meanwhile compounds II, III and V showed a significant free radical scavenging ability as well as antioxidant capacity. In addition, compounds I, IV, V and VI showed cytotoxicity against U87, A549 and MCF-7 cells. Overall, the new compound I showed valuable bioactive properties. Due to insufficient quantity of compound XIII, biological studies were not done.
KW - Citrus hystrix
KW - Pyranoflavones
KW - acetylcholinesterase inhibitory activities
KW - antioxidant
KW - cytotoxicity
KW - α-amylase
UR - https://www.scopus.com/pages/publications/85033704231
UR - https://www.scopus.com/pages/publications/85033704231#tab=citedBy
U2 - 10.1080/14786419.2017.1399386
DO - 10.1080/14786419.2017.1399386
M3 - Article
C2 - 29117732
AN - SCOPUS:85033704231
SN - 1478-6419
VL - 32
SP - 1721
EP - 1726
JO - Natural Product Research
JF - Natural Product Research
IS - 14
ER -