Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Cheng Lung Chen; Ling Ru Kuo; Shin Yu Lee; Yeu Kuang Hwu; Shang Wei Chou; Chia Chun Chen; Fu Hsiung Chang; Kung Hsuan Lin; Dzung Han Tsai; Yang Yuan Chen

doi:10.1016/j.biomaterials.2012.10.044

Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Cheng Lung Chen, Ling Ru Kuo, Shin Yu Lee, Yeu Kuang Hwu, Shang Wei Chou, Chia Chun Chen, Fu Hsiung Chang, Kung Hsuan Lin, Dzung Han Tsai, Yang Yuan Chen^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

112 引文斯高帕斯（Scopus）

摘要

FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

原文	英語
頁（從 - 到）	1128-1134
頁數	7
期刊	Biomaterials
卷	34
發行號	4
DOIs	https://doi.org/10.1016/j.biomaterials.2012.10.044
出版狀態	已發佈 - 2013 1月

ASJC Scopus subject areas

材料力學
陶瓷和複合材料
生物工程
生物物理學
生物材料

UN SDG

此研究成果有助於以下永續發展目標

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10.1016/j.biomaterials.2012.10.044

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引用此

@article{a84c5b01c0604fae97f0d430cb9e959a,

title = "Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles",

abstract = "FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.",

keywords = "Cancer therapy, FePt, Laser, Nanoparticle, Photothermal therapy, Thermal lens",

author = "Chen, {Cheng Lung} and Kuo, {Ling Ru} and Lee, {Shin Yu} and Hwu, {Yeu Kuang} and Chou, {Shang Wei} and Chen, {Chia Chun} and Chang, {Fu Hsiung} and Lin, {Kung Hsuan} and Tsai, {Dzung Han} and Chen, {Yang Yuan}",

note = "Funding Information: This work was supported by the National Science Council of the Republic of China under Grant No. NSC 100-2120-M-001-0019-MY3 . We thank Mr. Hong-Chi Chen for his help with microchamber fabrications, Dr.Chi-Keung Chan for his help with UV–visible absorption spectra analysis, Ms. Shu-Chen Shen for her help with confocal imaging analysis, and Mr. Cheng-Kuang Huang for his important contribution to the research effort.",

year = "2013",

month = jan,

doi = "10.1016/j.biomaterials.2012.10.044",

language = "English",

volume = "34",

pages = "1128--1134",

journal = "Biomaterials",

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AU - Chen, Cheng Lung

AU - Kuo, Ling Ru

AU - Lee, Shin Yu

AU - Hwu, Yeu Kuang

AU - Chou, Shang Wei

AU - Chen, Chia Chun

AU - Chang, Fu Hsiung

AU - Lin, Kung Hsuan

AU - Tsai, Dzung Han

AU - Chen, Yang Yuan

N1 - Funding Information: This work was supported by the National Science Council of the Republic of China under Grant No. NSC 100-2120-M-001-0019-MY3 . We thank Mr. Hong-Chi Chen for his help with microchamber fabrications, Dr.Chi-Keung Chan for his help with UV–visible absorption spectra analysis, Ms. Shu-Chen Shen for her help with confocal imaging analysis, and Mr. Cheng-Kuang Huang for his important contribution to the research effort.

PY - 2013/1

Y1 - 2013/1

N2 - FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

AB - FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

KW - Cancer therapy

KW - FePt

KW - Laser

KW - Nanoparticle

KW - Photothermal therapy

KW - Thermal lens

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Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

摘要

ASJC Scopus subject areas

UN SDG

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