Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Cheng Lung Chen, Ling Ru Kuo, Shin Yu Lee, Yeu Kuang Hwu, Shang Wei Chou, Chia Chun Chen, Fu Hsiung Chang, Kung Hsuan Lin, Dzung Han Tsai, Yang Yuan Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

81 引文 斯高帕斯(Scopus)

摘要

FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

原文英語
頁(從 - 到)1128-1134
頁數7
期刊Biomaterials
34
發行號4
DOIs
出版狀態已發佈 - 2013 一月 1

ASJC Scopus subject areas

  • 生物工程
  • 陶瓷和複合材料
  • 生物物理學
  • 生物材料
  • 材料力學

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