Phosphorylation alters tau distribution and elongates life span in drosophila

Po An Yeh*, Ching Jin Chang, Pong Hsien Tu, Harry Iain Wilson, Ju Yi Chien, Chiou Yang Tang, Ming Tsan Su


研究成果: 雜誌貢獻期刊論文同行評審

14 引文 斯高帕斯(Scopus)


The microtubule-associated tau protein has long been considered an axon-specific protein. Although many articles describe the subcellular localization of tau as regulated by post-modification in cultured cells, the intracellular regulation of its distribution in living animals has yet to be elucidated. In the present study, we demonstrate that phosphorylation alters tau polarity in Drosophila melanogaster. Interestingly, it was observed that expression of phosphorylation-incompetent tau impaired neurite growth more severely than either hyperphosphorylated or pseudophosphorylated tau. We also found that inducible expression of hyper- or pseudo-phosphorylated tau in adult flies strikingly prolonged their lifespan. This study offers an alternative tauopathic model by demonstrating that hyperphosphorylated tau has a beneficial effect on the nervous system. This is also corroborated by common effects seen in a variety of organisms in response to various stresses. We hope that this important animal model leads to a paradigm shift in thinking about hyperphosphorylated tau, which plays a protective role in nervous systems rather than the toxic role that many have historically been given to it.

頁(從 - 到)543-556
期刊Journal of Alzheimer's Disease
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • 一般神經科學
  • 臨床心理學
  • 老年病學和老年學
  • 精神病學和心理健康


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