Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins

Sandip Sambhaji Vagh; Bo Jhih Hou; Athukuri Edukondalu; Pin Ching Wang; Wenwei Lin

doi:10.1021/acs.orglett.0c04082

Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins

Sandip Sambhaji Vagh, Bo Jhih Hou, Athukuri Edukondalu, Pin Ching Wang, Wenwei Lin^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

27 引文斯高帕斯（Scopus）

摘要

A new method for the construction of functionalized furo[3,2-c]coumarins via MBH-type/acyl-transfer/Wittig reaction is reported. The current approach would open a new route for the simultaneous formation of two rings in a one-pot reaction which is accompanied by incorporation of a keto functionality on the furan ring by activating the terminal alkynoates with phosphine. Furthermore, this protocol could also be applicable to the internal alkynoates/propiolamides to generate the 2,3-disubstituted furo[3,2-c]coumarins/furo[3,2-c]quinolinones by excluding the acyl-transfer reaction.

原文	英語
頁（從 - 到）	842-846
頁數	5
期刊	Organic Letters
卷	23
發行號	3
DOIs	https://doi.org/10.1021/acs.orglett.0c04082
出版狀態	已發佈 - 2021 2月 5

ASJC Scopus subject areas

生物化學
物理與理論化學
有機化學

存取文件

10.1021/acs.orglett.0c04082

其它文件與鏈接

Link to publication in Scopus

CCDC 2039752: Experimental Crystal Structure Determination
Vagh, S. S. (Contributor), Hou, B.-J. (Contributor), Edukondalu, A. (Contributor), Wang, P.-C. (Contributor) & Lin, W. (Contributor), The Cambridge Structural Database, 2021
DOI: 10.5517/ccdc.csd.cc26gjgp, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc26gjgp&sid=DataCite
資料集: Dataset
CCDC 2039745: Experimental Crystal Structure Determination
Vagh, S. S. (Contributor), Hou, B.-J. (Contributor), Edukondalu, A. (Contributor), Wang, P.-C. (Contributor) & Lin, W. (Contributor), The Cambridge Structural Database, 2021
DOI: 10.5517/ccdc.csd.cc26gj7g, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc26gj7g&sid=DataCite
資料集: Dataset
CCDC 2039756: Experimental Crystal Structure Determination
Vagh, S. S. (Contributor), Hou, B.-J. (Contributor), Edukondalu, A. (Contributor), Wang, P.-C. (Contributor) & Lin, W. (Contributor), The Cambridge Structural Database, 2021
DOI: 10.5517/ccdc.csd.cc26gjlt, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc26gjlt&sid=DataCite
資料集: Dataset

引用此

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abstract = "A new method for the construction of functionalized furo[3,2-c]coumarins via MBH-type/acyl-transfer/Wittig reaction is reported. The current approach would open a new route for the simultaneous formation of two rings in a one-pot reaction which is accompanied by incorporation of a keto functionality on the furan ring by activating the terminal alkynoates with phosphine. Furthermore, this protocol could also be applicable to the internal alkynoates/propiolamides to generate the 2,3-disubstituted furo[3,2-c]coumarins/furo[3,2-c]quinolinones by excluding the acyl-transfer reaction.",

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AU - Vagh, Sandip Sambhaji

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AU - Edukondalu, Athukuri

AU - Wang, Pin Ching

AU - Lin, Wenwei

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AB - A new method for the construction of functionalized furo[3,2-c]coumarins via MBH-type/acyl-transfer/Wittig reaction is reported. The current approach would open a new route for the simultaneous formation of two rings in a one-pot reaction which is accompanied by incorporation of a keto functionality on the furan ring by activating the terminal alkynoates with phosphine. Furthermore, this protocol could also be applicable to the internal alkynoates/propiolamides to generate the 2,3-disubstituted furo[3,2-c]coumarins/furo[3,2-c]quinolinones by excluding the acyl-transfer reaction.

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Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 2039752: Experimental Crystal Structure Determination

CCDC 2039745: Experimental Crystal Structure Determination

CCDC 2039756: Experimental Crystal Structure Determination

引用此