Phosphine-Catalyzed Chemoselective Reduction/Elimination/Wittig Sequence for Synthesis of Functionalized 3-Alkenyl Benzofurans

Yan Cheng Liou, Heng Wei Wang, Athukuri Edukondalu, Wenwei Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

An efficient protocol for the construction of functionalized 3-alkenyl benzofurans is demonstrated under metal-free conditions using catalytic amount of phosphine proceeding an intramolecular Wittig reaction. This one-pot reaction initiated by the phospha-Michael addition of phosphine to O-acylated nitrostyrene, in which phosphine was in-situ-generated from the chemoselective reduction of phosphine oxide with PhSiH3, would provide the phosphorus ylide to result in the aforementioned multifunctionalized benzofuran via O-acylation/nitrous acid elimination/Wittig reaction.

原文英語
頁(從 - 到)3064-3069
頁數6
期刊Organic Letters
23
發行號8
DOIs
出版狀態已發佈 - 2021 四月 16

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

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