Ovarian cancer and antidepressants

Chi Shin Wu, Mong Liang Lu, Yin To Liao, Charles Tzu Chi Lee, Vincent Chin Hung Chen*


研究成果: 雜誌貢獻期刊論文同行評審

13 引文 斯高帕斯(Scopus)


Abstract Background The association between antidepressant use and ovarian cancer remains unclear. This study aimed to assess the ovarian cancer risk with antidepressant use in the general population. Methods Taiwan's National Health Insurance Research Database was used to identify 957 patients with ovarian cancer and 9570 controls. We used a conditional logistic regression model for data analysis, excluding a 1-year latent period before the diagnosis of ovarian cancer to account for the quantification of treatment duration. Results We found no increased risk of developing ovarian cancer among antidepressant users. Neither the duration of antidepressant use nor the average dose had a significant effect on the risk of ovarian cancer. In addition, timing of antidepressant use was not linked to ovarian cancer risk. However, we found the estimate of ovarian cancer risk increased slightly among subjects under 50 years (adjusted OR = 2.03, 95% CI [0.82, 5.02]), although this association was still statistically insignificant (p = 0.12). Conclusions There was no association between risk of ovarian cancer and use of antidepressant drugs. Whether or not there is possible risk of using antidepressant whose mechanism of action involves dopamine and norepinephrine warrants further investigation.

頁(從 - 到)579-584
出版狀態已發佈 - 2015 5月 1

ASJC Scopus subject areas

  • 實驗與認知心理學
  • 腫瘤科
  • 精神病學和心理健康


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