Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles

Chia Yu Wu; Kwunmin Chen

doi:10.1002/slct.201800726

Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles

Chia Yu Wu
, Kwunmin Chen^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

9 引文斯高帕斯（Scopus）

摘要

We have developed an efficient synthetic method for the production of substituted tetrahydropyrano[2, 3-c]pyrazoles using (E)-2-nitro-1,3-enynes, 1-aryl-3-substituted pyrazolones and methyl vinyl ketone. The sequential, one-pot reaction proceeded smoothly to give the desired products in high to excellent yields and stereoselectivities in the presence of a quinine-derived squaramide organocatalyst.

原文	英語
頁（從 - 到）	3500-3504
頁數	5
期刊	ChemistrySelect
卷	3
發行號	12
DOIs	https://doi.org/10.1002/slct.201800726
出版狀態	已發佈 - 2018 3月 29

ASJC Scopus subject areas

一般化學

存取文件

10.1002/slct.201800726

其它文件與鏈接

CCDC 1552396: Experimental Crystal Structure Determination
Wu, C.-Y. (Creator) & Chen, K. (Creator), Unknown Publisher, 2019
DOI: 10.5517/ccdc.csd.cc1p3d9h, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1p3d9h&sid=DataCite
資料集: Dataset
CCDC 1552399: Experimental Crystal Structure Determination
Wu, C.-Y. (Creator) & Chen, K. (Creator), Unknown Publisher, 2019
DOI: 10.5517/ccdc.csd.cc1p3ddl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1p3ddl&sid=DataCite
資料集: Dataset

引用此

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title = "Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles",

abstract = "We have developed an efficient synthetic method for the production of substituted tetrahydropyrano[2, 3-c]pyrazoles using (E)-2-nitro-1,3-enynes, 1-aryl-3-substituted pyrazolones and methyl vinyl ketone. The sequential, one-pot reaction proceeded smoothly to give the desired products in high to excellent yields and stereoselectivities in the presence of a quinine-derived squaramide organocatalyst.",

keywords = "(E)-2-nitro-1,3-enynes, Michael reaction, organocatalysis, pyrazolone, stereoselectivity",

author = "Wu, \{Chia Yu\} and Kwunmin Chen",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = mar,

day = "29",

doi = "10.1002/slct.201800726",

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T1 - Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles

AU - Wu, Chia Yu

AU - Chen, Kwunmin

PY - 2018/3/29

Y1 - 2018/3/29

N2 - We have developed an efficient synthetic method for the production of substituted tetrahydropyrano[2, 3-c]pyrazoles using (E)-2-nitro-1,3-enynes, 1-aryl-3-substituted pyrazolones and methyl vinyl ketone. The sequential, one-pot reaction proceeded smoothly to give the desired products in high to excellent yields and stereoselectivities in the presence of a quinine-derived squaramide organocatalyst.

AB - We have developed an efficient synthetic method for the production of substituted tetrahydropyrano[2, 3-c]pyrazoles using (E)-2-nitro-1,3-enynes, 1-aryl-3-substituted pyrazolones and methyl vinyl ketone. The sequential, one-pot reaction proceeded smoothly to give the desired products in high to excellent yields and stereoselectivities in the presence of a quinine-derived squaramide organocatalyst.

KW - (E)-2-nitro-1,3-enynes

KW - Michael reaction

KW - organocatalysis

KW - pyrazolone

KW - stereoselectivity

UR - https://www.scopus.com/pages/publications/85045132575

UR - https://www.scopus.com/pages/publications/85045132575#tab=citedBy

U2 - 10.1002/slct.201800726

DO - 10.1002/slct.201800726

M3 - Article

AN - SCOPUS:85045132575

SN - 2365-6549

VL - 3

SP - 3500

EP - 3504

JO - ChemistrySelect

JF - ChemistrySelect

IS - 12

ER -

Organocatalytic Three-Component, One-Pot Reaction of Highly Substituted Tetrahydropyrano[2, 3-c]pyrazoles

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 1552396: Experimental Crystal Structure Determination

CCDC 1552399: Experimental Crystal Structure Determination

引用此