Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction

Siang En Syu; Yu Ting Lee; Yeong Jiunn Jang; Wenwei Lin

doi:10.1021/jo102143r

Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction

Siang En Syu
, Yu Ting Lee
, Yeong Jiunn Jang
, Wenwei Lin^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

16 引文斯高帕斯（Scopus）

摘要

A highly chemoselective PPh₃-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.

原文	英語
頁（從 - 到）	2888-2891
頁數	4
期刊	Journal of Organic Chemistry
卷	76
發行號	8
DOIs	https://doi.org/10.1021/jo102143r
出版狀態	已發佈 - 2011 4月 15

ASJC Scopus subject areas

有機化學

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10.1021/jo102143r

其它文件與鏈接

CCDC 785233: Experimental Crystal Structure Determination
Syu, S.-E. (Creator), Lee, Y.-T. (Creator), Jang, Y.-J. (Creator) & Lin, W. (Creator), Unknown Publisher, 2012
DOI: 10.5517/ccvc33d, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccvc33d&sid=DataCite
資料集: Dataset
CCDC 785234: Experimental Crystal Structure Determination
Syu, S.-E. (Creator), Lee, Y.-T. (Creator), Jang, Y.-J. (Creator) & Lin, W. (Creator), Unknown Publisher, 2012
DOI: 10.5517/ccvc34f, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccvc34f&sid=DataCite
資料集: Dataset
CCDC 785237: Experimental Crystal Structure Determination
Syu, S.-E. (Creator), Lee, Y.-T. (Creator), Jang, Y.-J. (Creator) & Lin, W. (Creator), Unknown Publisher, 2012
DOI: 10.5517/ccvc37j, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccvc37j&sid=DataCite
資料集: Dataset

引用此

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title = "Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction",

abstract = "A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.",

author = "Syu, \{Siang En\} and Lee, \{Yu Ting\} and Jang, \{Yeong Jiunn\} and Wenwei Lin",

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doi = "10.1021/jo102143r",

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journal = "Journal of Organic Chemistry",

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T1 - Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction

AU - Syu, Siang En

AU - Lee, Yu Ting

AU - Jang, Yeong Jiunn

AU - Lin, Wenwei

PY - 2011/4/15

Y1 - 2011/4/15

N2 - A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.

AB - A highly chemoselective PPh3-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.

UR - https://www.scopus.com/pages/publications/79953870516

UR - https://www.scopus.com/pages/publications/79953870516#tab=citedBy

U2 - 10.1021/jo102143r

DO - 10.1021/jo102143r

M3 - Article

AN - SCOPUS:79953870516

SN - 0022-3263

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 8

ER -

Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-baylis-hillman reaction

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 785233: Experimental Crystal Structure Determination

CCDC 785234: Experimental Crystal Structure Determination

CCDC 785237: Experimental Crystal Structure Determination

引用此