Organocatalytic tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide: One-pot syntheses of highly functional alkenes

De Wei Wang, Siang En Syu, Yi Ting Hung, Pei Yi Chen, Chia Jui Lee, Ko Wei Chen, Yu Jhang Chen, Wenwei Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

10 引文 斯高帕斯(Scopus)

摘要

An EtPPh2- or PPh3-catalyzed tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide is developed. Its further application in one-pot syntheses of highly functional alkenes starting from aldehydes, alkyl vinyl ketones, and amides is realized. A wide variety of highly functional α,β-unsaturated ketones can be furnished in 68-99% yields with high stereoselectivity (E/Z up to 98:2) within overall 3-29.5 h.

原文英語
頁(從 - 到)363-366
頁數4
期刊Organic and Biomolecular Chemistry
9
發行號2
DOIs
出版狀態已發佈 - 2011 一月 21

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

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