摘要
Metal-free addition of salicylhydrazones to electron deficient internal alkynes catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) to yield oxa-bridged 2,6-epoxybenzo[b][1,5]oxazocine heterocycles was achieved. The demonstrated protocol proceeds through an o-quinone methide formation, aza-Michael addition, stereoselective protonation, enamine promoted aromatization, O,O-acetalization and O,N-aminalization sequence to provide privileged heterocycles in good yields with high diastereoselectivities.
原文 | 英語 |
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頁(從 - 到) | 6048-6051 |
頁數 | 4 |
期刊 | Chemical Communications |
卷 | 54 |
發行號 | 47 |
DOIs | |
出版狀態 | 已發佈 - 2018 |
ASJC Scopus subject areas
- 催化
- 電子、光磁材料
- 陶瓷和複合材料
- 一般化學
- 表面、塗料和薄膜
- 金屬和合金
- 材料化學
指紋
深入研究「Organocatalytic synthesis of densely functionalized oxa-bridged 2,6-epoxybenzo[: B] [1,5]oxazocine heterocycles」主題。共同形成了獨特的指紋。資料集
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CCDC 1819727: Experimental Crystal Structure Determination
Gurubrahamam, R. (Creator), Nagaraju, K. (Creator) & Chen, K. (Creator), Unknown Publisher, 2018
DOI: 10.5517/ccdc.csd.cc1z2kwh, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1z2kwh&sid=DataCite
資料集: Dataset