Organocatalytic one-pot asymmetric synthesis of functionalized spiropyrazolones: Via a Michael-aldol sequential reaction

Mamatha Amireddy, Kwunmin Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

21 引文 斯高帕斯(Scopus)

摘要

An efficient organocatalytic method was developed for synthesizing functionalized spiropyrazolone derivatives containing four contiguous stereogenic centres by using a Michael-aldol consecutive reaction. We applied a quinine-derived squaramide catalyst to catalyze a reaction between 3-methyl-1-aryl-2-pyrazolin-5-ones and (E)-5-nitro-6-aryl-hex-5-en-2-ones, realizing the desired spiropyrazolones in moderate-to-good yields (up to 80%) with good-to-excellent stereoselectivities (up to >20:1 dr, 94% ee).

原文英語
頁(從 - 到)77474-77480
頁數7
期刊RSC Advances
6
發行號81
DOIs
出版狀態已發佈 - 2016 一月 1

ASJC Scopus subject areas

  • 化學 (全部)
  • 化學工程 (全部)

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