Organocatalytic enantioselective direct vinylogous michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes

Yi Ru Chen, Utpal Das, Meng Hsien Liu, Wenwei Lin

研究成果: 雜誌貢獻文章

30 引文 斯高帕斯(Scopus)

摘要

A highly efficient Michael addition of α,β-unsaturated γ-butyrolactam to various β-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.

原文英語
頁(從 - 到)1985-1992
頁數8
期刊Journal of Organic Chemistry
80
發行號3
DOIs
出版狀態已發佈 - 2015 二月 6

ASJC Scopus subject areas

  • Organic Chemistry

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