Organocatalytic Diastereoselective Synthesis of Diazoaryl-benzo[b]azepine Derivatives

Koppanathi Nagaraju, Ramani Gurubrahamam, Ramani Gurubrahamam, Kwunmin Chen

研究成果: 雜誌貢獻文章

摘要

To construct multisubstituted seven-membered nitrogenous heterocyclic scaffolds, an efficient method, employing 2-aminoaryl N-monosubstituted hydrazones and 2-oxo-3-butenoates under Brønsted acid catalysis, has been developed. This strategy highlights the umpolung reactivity of 2-aminobenzaldehyde arylhydrazones toward 2-oxo-3-butenoates to afford (E)-diazoaryl-benzo[b]azepine derivatives in excellent yields (89-99%) and with high diastereoselectivities (>19:1 dr).

原文英語
頁(從 - 到)7060-7067
頁數8
期刊Journal of Organic Chemistry
85
發行號11
DOIs
出版狀態已發佈 - 2020 六月 5

ASJC Scopus subject areas

  • Organic Chemistry

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