Optimization of separation and online sample concentration of N,N-dimethyltryptamine and related compounds using MEKC

Man Juing Wang, Chih Hsin Tsai, Wei Ya Hsu, Ju Tsung Liu, Cheng Huang Lin

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

The optimal separation conditions and online sample concentration for N,N-dimethyltryptamine (DMT) and related compounds, including α-methyltryptamine (AMT), 5-methoxy-AMT (5-MeO-AMT), N,N-diethyltryptamine (DET), N,N-dipropyltryptamine (DPT), N,N-dibutyltryptamine (DBT), N,N-diisopropyltryptamine (DiPT), 5-methoxy-DMT (5-MeO-DMT), and 5-methoxy-N,N-DiPT (5-MeO-DiPT), using micellar EKC (MEKC) with UV-absorbance detection are described. The LODs (S/N = 3) for MEKC ranged from 1.0 - 1.8 μg/mL. Use of online sample concentration methods, including sweeping-MEKC and cation-selective exhaustive injection-sweep-MEKC (CSEI-sweep-MEKC) improved the LODs to 2.2 - 8.0 ng/mL and 1.3 - 2.7 ng/mL, respectively. In addition, the order of migration of the nine tryptamines was investigated. A urine sample, obtained by spiking urine collected from a human volunteer with DMT, was also successfully examined.

原文英語
頁(從 - 到)441-445
頁數5
期刊Journal of Separation Science
32
發行號3
DOIs
出版狀態已發佈 - 2009 二月 1

    指紋

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation

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