TY - JOUR
T1 - Optical trapping of a spherically symmetric rayleigh sphere
T2 - A model for optical tweezers upon cells
AU - Chang, Yi Ren
AU - Hsu, Long
AU - Chi, Sien
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Optical tweezers have become a popular manipulation and force measurement tool in cellular and molecular biology. However, there is still a lack of a sophisticated model for optical tweezers on trapping cells. In this paper, we present a novel model for optical tweezers to calculate the stiffness of trapping force upon a spherically symmetric Rayleigh sphere, which stimulates a common biological cell. A numerical simulation of this model shows that the stiffness of an optical tweezers system in trapping a cell is significantly smaller than that in trapping a polystyrene bead of the same size. Furthermore, under a small variant condition of the refractive index, the proposed model provides an approximate method which requires only the radial distribution of the trapped cell's refractive index for calculating the stiffness.
AB - Optical tweezers have become a popular manipulation and force measurement tool in cellular and molecular biology. However, there is still a lack of a sophisticated model for optical tweezers on trapping cells. In this paper, we present a novel model for optical tweezers to calculate the stiffness of trapping force upon a spherically symmetric Rayleigh sphere, which stimulates a common biological cell. A numerical simulation of this model shows that the stiffness of an optical tweezers system in trapping a cell is significantly smaller than that in trapping a polystyrene bead of the same size. Furthermore, under a small variant condition of the refractive index, the proposed model provides an approximate method which requires only the radial distribution of the trapped cell's refractive index for calculating the stiffness.
KW - Biophotonics
KW - Optical tweezers
KW - Rayleigh scattering
UR - http://www.scopus.com/inward/record.url?scp=12244274649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12244274649&partnerID=8YFLogxK
U2 - 10.1016/j.optcom.2004.10.066
DO - 10.1016/j.optcom.2004.10.066
M3 - Article
AN - SCOPUS:12244274649
SN - 0030-4018
VL - 246
SP - 97
EP - 105
JO - Optics Communications
JF - Optics Communications
IS - 1-3
ER -