摘要
Optical resolution of racemic 5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid 2 with L-amino acid methyl ester via the diastereomers formation was investigated. Treatment of racemic 5-oxo-1-phenylpyrazolidine-3-carboxylic acid 2 with L-valine methyl ester gave diastereomers with a total yield of 86%. The diastereomeric dipeptides can be easily separated by flash column chromatography. Acidic cleavage of the derived diastereomers gave both the optically pure (+)-(R)- and (-)-(S)-5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid ((+)-(R)-2 and (-)-(S)-2) with a total yield of 94% and 95%, respectively.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 626-631 |
| 頁數 | 6 |
| 期刊 | Journal of the Chinese Chemical Society |
| 卷 | 55 |
| 發行號 | 3 |
| DOIs | |
| 出版狀態 | 已發佈 - 2008 |
ASJC Scopus subject areas
- 一般化學
指紋
深入研究「Optical resolution of 5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid as a new organocatalyst for organic reactions」主題。共同形成了獨特的指紋。資料集
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CCDC 645805: Experimental Crystal Structure Determination
Tzeng, Z. (Creator), Yang, S. (Creator), Liu, P. (Creator) & Chen, K. (Creator), Unknown Publisher, 2009
DOI: 10.5517/ccpp0fs, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccpp0fs&sid=DataCite
資料集: Dataset