Optical Coherence Tomography/Angiography-Guided Tumor Ablation with a Continuous-Wave Laser Diode

Meng Tsan Tsai, Wen Ju Chen, Ting Yen Tsai, Hsiang Chieh Lee, Chun Chieh Wang, Ya Ju Lee

研究成果: 雜誌貢獻文章

摘要

Laser ablation can be an effective modality for treatment, but it is complicated to apply continuous-wave (CW) light sources for laser ablation because of the unpredictable photothermal damage. In this study, an integrated theranostic system combining a low-cost CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for the in vivo ablation of tumor tissues. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin tumor on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

原文英語
文章編號9016031
頁(從 - 到)43191-43199
頁數9
期刊IEEE Access
8
DOIs
出版狀態已發佈 - 2020

ASJC Scopus subject areas

  • Computer Science(all)
  • Materials Science(all)
  • Engineering(all)

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