One-Pot Synthesis of N-Monosubstituted Ureas from Nitriles via Tiemann Rearrangement

Chien Hong Wang, Tsung Han Hsieh, Chia Chi Lin, Wen Hsiung Yeh, Chih An Lin, Tun Cheng Chien

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Amidoximes, obtained from the reaction of nitriles with hydroxylamine, underwent Tiemann rearrangement in the presence of benzenesulfonyl chlorides (TsCl or o-NsCl) to form the N-substituted cyanamides. Subsequently, acidic hydrolysis of the cyanamides afforded the corresponding N-monosubstituted ureas. The synthesis of N-monosubstituted ureas from nitriles was accomplished by three steps in one pot, which provides a direct access to versatile N-monosubstituted urea derivatives from a wide variety of nitriles.

原文英語
文章編號st-2015-u0285-l
頁(從 - 到)1823-1826
頁數4
期刊Synlett
26
發行號13
DOIs
出版狀態已發佈 - 2015 八月 12

ASJC Scopus subject areas

  • Organic Chemistry

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