TY - JOUR
T1 - On-line identification of lysergic acid diethylamide (LSD) in tablets using a combination of a sweeping technique and micellar electrokinetic chromatography/77 K fluorescence spectroscopy
AU - Fang, Ching
AU - Liu, Ju Tsung
AU - Lin, Cheng Huang
PY - 2003/3
Y1 - 2003/3
N2 - This work describes a novel method for the accurate determination of lysergic acid diethylamide (LSD) in tablets. A technique involving sweeping-micellar electrokinetic chromatography (MEKC) was used for the initial on-line concentration and separation, after which a cryogenic molecular fluorescence experiment was performed at 77 K. Using this approach, not only the separation of LSD from the tablet extract was achieved, but on-line spectra were readily distinguishable and could be unambiguously assigned. The results are in agreement with analyses by gas chromatography-mass spectrometry (GC-MS). Thus, this method, which was found to be accurate, sensitive and rapid, has the potential for use as a reliable complementary method to GC-MS in such analyses.
AB - This work describes a novel method for the accurate determination of lysergic acid diethylamide (LSD) in tablets. A technique involving sweeping-micellar electrokinetic chromatography (MEKC) was used for the initial on-line concentration and separation, after which a cryogenic molecular fluorescence experiment was performed at 77 K. Using this approach, not only the separation of LSD from the tablet extract was achieved, but on-line spectra were readily distinguishable and could be unambiguously assigned. The results are in agreement with analyses by gas chromatography-mass spectrometry (GC-MS). Thus, this method, which was found to be accurate, sensitive and rapid, has the potential for use as a reliable complementary method to GC-MS in such analyses.
KW - Gas chromatography-mass spectrometry
KW - Low-temperature fluorescence spectroscopy
KW - Lysergic acid diethylamide (LSD)
KW - Micellar electrokinetic chromatography
KW - Sweeping
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U2 - 10.1002/elps.200390118
DO - 10.1002/elps.200390118
M3 - Article
C2 - 12658691
AN - SCOPUS:0347765632
SN - 0173-0835
VL - 24
SP - 1025
EP - 1030
JO - Electrophoresis
JF - Electrophoresis
IS - 6
ER -