Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo; Ara Ghazaryan; Chien Hsin Tso; Po Sheng Hu; Wei Liang Chen; Tsung Rong Kuo; Sung Jan Lin; Shean Jen Chen; Chia Chun Chen; Chen Yuan Dong

doi:10.1063/1.3701135

Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo
, Ara Ghazaryan
, Chien Hsin Tso
, Po Sheng Hu
, Wei Liang Chen
, Tsung Rong Kuo
, Sung Jan Lin
, Shean Jen Chen
, Chia Chun Chen^*
, Chen Yuan Dong

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

4 引文斯高帕斯（Scopus）

摘要

Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

原文	英語
文章編號	213701
期刊	Applied Physics Letters
卷	100
發行號	21
DOIs	https://doi.org/10.1063/1.3701135
出版狀態	已發佈 - 2012 5月 21

ASJC Scopus subject areas

物理與天文學（雜項）

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10.1063/1.3701135

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引用此

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title = "Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles",

abstract = "Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.",

author = "Wen Lo and Ara Ghazaryan and Tso, \{Chien Hsin\} and Hu, \{Po Sheng\} and Chen, \{Wei Liang\} and Kuo, \{Tsung Rong\} and Lin, \{Sung Jan\} and Chen, \{Shean Jen\} and Chen, \{Chia Chun\} and Dong, \{Chen Yuan\}",

note = "Funding Information: Funding support for this work was provided by Taiwan{\textquoteright}s National Science Council (NSC 99-2221-E-002-096-MY3, 99-2221-E-002-096-MY3), National Health Research Institute (NHRI-EX100-10041EI), Center for Quantum Science and Engineering of National Taiwan University (CQSE-99R80870), and National Taiwan University (NTU-99R70409).",

year = "2012",

month = may,

day = "21",

doi = "10.1063/1.3701135",

language = "English",

volume = "100",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics Inc.",

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TY - JOUR

T1 - Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

AU - Lo, Wen

AU - Ghazaryan, Ara

AU - Tso, Chien Hsin

AU - Hu, Po Sheng

AU - Chen, Wei Liang

AU - Kuo, Tsung Rong

AU - Lin, Sung Jan

AU - Chen, Shean Jen

AU - Chen, Chia Chun

AU - Dong, Chen Yuan

N1 - Funding Information: Funding support for this work was provided by Taiwan’s National Science Council (NSC 99-2221-E-002-096-MY3, 99-2221-E-002-096-MY3), National Health Research Institute (NHRI-EX100-10041EI), Center for Quantum Science and Engineering of National Taiwan University (CQSE-99R80870), and National Taiwan University (NTU-99R70409).

PY - 2012/5/21

Y1 - 2012/5/21

N2 - Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

AB - Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

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U2 - 10.1063/1.3701135

DO - 10.1063/1.3701135

M3 - Article

AN - SCOPUS:84861831529

SN - 0003-6951

VL - 100

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 21

M1 - 213701

ER -

Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

摘要

ASJC Scopus subject areas

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指紋

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