Object-oriented synthetic approach toward angular and linear fused pyrazoloquinolines of biological importance with InCl3 catalyst

Thangaraj Arasakumar, Sadasivam Mathusalini, Krishnasamy Lakshmi, Palathurai Subramaniam Mohan*, Athar Ata, Chia Her Lin

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

10 引文 斯高帕斯(Scopus)

摘要

A simple and short approach for the synthesis of pyrazolo[3,4-b]quinoline (3a-3p) and pyrazolo[4,3-c]quinoline (6a-6 h) using various Lewis acid catalysts was developed. InCl3 was found to be more effective in providing greater yield of products compared to Yb(OTf)3, Sc(OTf)3, SnCl4, AlCl3, TiCl4, ZnCl2, FeCl3, and BF3 · Et2O. Moreover, a comparison of conventional and microwave methods has revealed that the latter method is more efficient compared to former one. Structures were confirmed by Fourier transform infrared, mass spectrometry, 1H and 13C NMR, X-ray crystallography, and elemental analyses. All of the synthesized compounds were evaluated for α-glucosidase inhibitory activity. Compounds 3a, 3p, 3i, 3 h, 3k, 3o, and 3 g exhibited anti α-glucosidase inhibitory activity with IC50 values of 57.5, 60.3, 65.9, 71.9, 80.8, 123.7, and 126.4 μM, respectively, which is quite comparable to the standard drug acarbose (IC50 = 115.8 μM).

原文英語
頁(從 - 到)232-241
頁數10
期刊Synthetic Communications
46
發行號3
DOIs
出版狀態已發佈 - 2016 2月 1
對外發佈

ASJC Scopus subject areas

  • 有機化學

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